Table 2

Trials testing passionflower


Study Design

Sample Population



Length of Treatment


Direction of Evidence

Reported Adverse Events

Bourin (1997) [34]



Parallel Group

182 outpatients with adjustment disorder with anxious mood

Euphytose1; 2 tablets, 3 times a day

Placebo tablets

28 days

Significant reduction in HAMA scores (from D7 to D28) in favour of Euphytose treatment


No serious AEs.

Dry mouth




Akhondzadeh (2001) [32]


Double-blind; Parallel group

36 outpatients with DSM-IV for GAD for at least 6 months

45 drops/day of Passiflora extract plus placebo tablet

Oxazepam 30 mg/day plus placebo drops

4 weeks

Decrease in HAMA for both treatments2; overall no

significant difference in efficacy between treatments


Higher impairment of job performance in oxazepam group; overall no significant difference in total side effects3

Movafegh (2008) [33]


Double-blind; Parallel Group

60 patients undergoing inguinal herniorrhaphy

Oral Passiflora incarnata (500 mg, Passipy™ IranDarouk)


Given as pre-medication 90 minutes before surgery

NRS anxiety scores were significantly

lower in the passiflora group


Not reported

AEs: Adverse events; HAMA: Hamilton Anxiety Scale; DMS-IV: Diagnostic and Statistical Manual of Mental Disorders, fourth edition; GAD: generalized anxiety disorder; NRS: numerical rating scale.

1. Combination of Crataegus oxyacantha (10 mg), Ballota foetida (10 mg), Passiflora incarnata (40 mg), Valeriana officinalis (50 mg), Cola nitida (15 mg) and Paullinia cupana (15 mg).

2. D4 oxazepam; D7 passiflora.

3. Passiflora, mild/moderate: Dizziness, Drowsiness, Confusion, Ataxia, Allergic reaction, Impairment of job performance.

Lakhan and Vieira Nutrition Journal 2010 9:42   doi:10.1186/1475-2891-9-42

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