Table 3

Systematic reviews on Vitamin D for prevention or treatment (in chronological order)

Area

Number

of studies

Type

Doses

Conclusion

Reference


Cardiovascular events

17

Prospective

~1000IU

S not SS

162


Cardiometabolic outcomes

31

Observ/Trial

Range

No effect

163


Fracture prevention

7

Randomised

10-20 mcg

+ Ca

No effect

Reduced risk

164

164


Physical performance

8

8

Observational

Intervention

-

-

Positive (5/8)

Mixed

165

165


Kidney disease

(-dialysis)

16

RCT

-

Uncertain

166


Kidney disease (+dialysis)

60

RCT

-

Uncertain

167


Cystic fibrosis

3

(q)RCT

800-1600IU

No effect

168


Risk of falling

8

RCT

700-1000IU

200-600IU

Reduced risk

No effect

169

169


Hypertension

11

RCT

-

S - SS

170


Risk of falling

111*

RT or interv.

-

No effect

171


Fracture prevention

45

(q)RCT

-

+Ca

No effect

S not SS

172

172


Risk of Type 1 diabetes

5

Observational

-

Uncertain

136


Parathyroid hormone

52

Intervention

_

Decrease

173


Mortality

18

RCT

2300-2000IU

Uncertain

174


Risk of fall/fracture

9

-

-

Decrease (trend)

175


Risk of fracture

12

RCT

700-800IU

400IU

Decrease (trend)

No effect

176

176


Risk of fall

10

RCT

-

Decrease

177


Bone density Fracture

17

17

RCT

RCT

-

-

Uncertain

Reduction

178


S not SS: Small effect - not statistically significant (sub-groups are discounted); RCT: Randomised controlled trial {(q) - quasi}; * Multiple factor study.

Zhang and Naughton Nutrition Journal 2010 9:65   doi:10.1186/1475-2891-9-65

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