Table 5

Serum albumin levels and survival - other cancer sites

First author, year of publication, place

Year of data collection

Study design, Sample size

Cancer type

Groups being compared

RR (95%Cl), p-value

Variables adjusted for


Barreto-Andrade JC, 2009, Mexico [87]

January 1986 to May 2006

Retrospective, 61

Soft Tissue Sarcoma

Low <3.5 g/dL

Normal >=3.5 g/dL

Univariate: p = 0.03

Multivariate: p = 0.02

Age, sex, obesity, previous biopsy performed, histology, site histologic grade, stage, tumor resectability, tumor size, performance status, surgical risk


Seve P, 2006, France [47]

January 1, 1998 to December 31, 2004

Retrospective consecutive case series, 317

Unknown Primary

Low <3.5 g/dL

Normal >=3.5 g/dL

Univariate: Median survival in days

Low: 62; Normal: 318; p < 0.0001

Multivariate: 2.70 (1.79-4.07), <.0001

Age, sex, ACE-27 score, No. of sites, liver metastasis, peritoneal mets, PS, LDH, ALP, hemoglobin, platelets


Alici S, 2003, Turkey [88]

1989 to 1998

Retrospective, 110

Non-Hodgkin's Lymphoma

Normal

Low

Univariate: p = 0.005

Multivariate: p = 0.022

Age, sex, stage, PS, B symptoms, treatment regimen, remission status, histology, bulky disease, LDH, ESR, extranodal involvement


Medow MA, 2002, USA [89]

July 1993 to June 1997

Retrospective consecutive case series, 406

Head and neck

<3.85 g/dL

>=3.85 g/dL

TNM stage IV or recurrent disease

Median survival:

<3.85 g/dL: 404 days (286-532 days),

>=3.85 g/dL: 625 days (536-1032 days)

Age, tumor stage, self-reported functional class, systolic blood

pressure, diastolic blood pressure, and BMI


Ljungberg B, 2000, Sweden [90]

April 1982 to February 1999

Retrospective consecutive case series, 106

Renal cell

Continuous variable

Univariate: NA, p = 0.063

Multivariate: 1.01 (0.45 - 2.28), 0.96

Age, gender, tumor size, PS, solitary metastases, calcium, ESR, nuclear grade, DNA ploidy and vein invasion


Schwartzbaum JA, 1999, USA [91]

February 1, 1993 to December 31, 1995

A convenience sample, 24

Glioblastoma multiforme

1st Quartile

(2.6-3.1 g/dL)

2nd Quartile

3rd Quartile

4th Quartile

(3.9-4.4 g/dL)

Multivariate:

2nd= 1.2

3rd= 0.1

4th =0.1

p = 0.007

Age, sex, chemotherapy, serum iron, radiation


Aparicio J, 1998, Spain [92]

1970 to 1993

Retrospective, 116

Ewing's sarcoma

Low: <=3.5 g/dL

Normal: >3.5 g/dL

Univariate: 5 year survival 48% in normal and 7% in low; median survival 52 months in normal and 6 months in low, p < 0.0001

Multivariate: p = 0.001

Age, sex, tumor site, maximum tumor diameter, extent of disease, PS, duration of symptoms before diagnosis, systemic symptoms, leukocytes and hemoglobin, ESR, LDH, histologic pattern, percent of tumor necrosis on the initial biopsy specimen


Citterio G, 1997, Italy [93]

1988 onwards

Retrospective consecutive case series, 109

Renal cell

NA

Univariate: p < 0.01

Age, sex, DFI, PS, stage at diagnosis, grading, number and type of metastatic sites, nephrectomy, blood levels of hemoglobin, creatinine, calcium, LDH, ferritin, ALP, triglycerides


Gupta and Lis Nutrition Journal 2010 9:69   doi:10.1186/1475-2891-9-69

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