Table 2

Differences in binding of some antiepileptic drugs to parenteral nutrition fluids and to human serum

Drug

Parenteral nutrition formulas

Fluid † (μmol/L)

Serum (μmol/L)

Average Competitive Binding Difference ‡


Carbamazepine

A

16.1

2.1

77%

B

16.9

1.7

82%

C

17.8

2.5

75%

D

16.9

2.1

78%

E

17.3

2.5

75%

Phenytoin

A

32.4

88.7

-46%

B

35.0

80.6

-39%

C

34.1

74.8

-37%

D

31.7

67.9

-36%

E

31.7

68.3

-37%

Phenobarbital

A

56.8

75.9

-14%

B

58.9

74.8

-12%

C

61.1

77.4

-12%

D

58.5

77.4

-14%

E

61.9

78.0

-12%

A

181.8

1290.2

-75%

Valproic acid

B

194.0

1179.6

-72%

C

156.7

1061.6

-74%

D

127.0

993.2

-77%

E

207.6

998.1

-66%


†A = 4.5% Travasol_/25% dextrose; B = 4.5% Travasol_/10% dextrose; C = 4.5% Travasol_/5% dextrose; D = 2.5% Travasol_/10% dextrose; E = 2.5% Travasol_/5% dextrose. ‡100% × (Concentration in Fluid - Concentration in Serum)/(Concentration in Fluid + Concentration in Serum).

Salih et al. Nutrition Journal 2010 9:71   doi:10.1186/1475-2891-9-71

Open Data