Table 2 |
||||
|
Differences in binding of some antiepileptic drugs to parenteral nutrition fluids and to human serum |
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|
Drug |
Parenteral nutrition formulas |
Fluid † (μmol/L) |
Serum (μmol/L) |
Average Competitive Binding Difference ‡ |
|
|
||||
|
Carbamazepine |
A |
16.1 |
2.1 |
77% |
|
B |
16.9 |
1.7 |
82% |
|
|
C |
17.8 |
2.5 |
75% |
|
|
D |
16.9 |
2.1 |
78% |
|
|
E |
17.3 |
2.5 |
75% |
|
|
Phenytoin |
A |
32.4 |
88.7 |
-46% |
|
B |
35.0 |
80.6 |
-39% |
|
|
C |
34.1 |
74.8 |
-37% |
|
|
D |
31.7 |
67.9 |
-36% |
|
|
E |
31.7 |
68.3 |
-37% |
|
|
Phenobarbital |
A |
56.8 |
75.9 |
-14% |
|
B |
58.9 |
74.8 |
-12% |
|
|
C |
61.1 |
77.4 |
-12% |
|
|
D |
58.5 |
77.4 |
-14% |
|
|
E |
61.9 |
78.0 |
-12% |
|
|
A |
181.8 |
1290.2 |
-75% |
|
|
Valproic acid |
B |
194.0 |
1179.6 |
-72% |
|
C |
156.7 |
1061.6 |
-74% |
|
|
D |
127.0 |
993.2 |
-77% |
|
|
E |
207.6 |
998.1 |
-66% |
|
|
|
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|
†A = 4.5% Travasol_/25% dextrose; B = 4.5% Travasol_/10% dextrose; C = 4.5% Travasol_/5% dextrose; D = 2.5% Travasol_/10% dextrose; E = 2.5% Travasol_/5% dextrose. ‡100% × (Concentration in Fluid - Concentration in Serum)/(Concentration in Fluid + Concentration in Serum). |
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|
Salih et al. Nutrition Journal 2010 9:71 doi:10.1186/1475-2891-9-71 |
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