Table 3 |
||
|
Protein binding of antiepileptic drugs |
||
|
Drug |
Protein binding |
Candidate for free drug |
|
|
||
|
Old generation AED |
||
|
Phenobarbital |
40% |
No |
|
Phenytoin |
90% |
Yes |
|
Carbamazepine |
80% |
Yes |
|
Valproic acid |
90-95% |
Yes |
|
Primidone |
15% |
No |
|
Ethosuximide |
0% |
No |
|
New generation AED |
||
|
Eslicarbazepine acetate |
30 |
No |
|
Felbamate |
25 |
No |
|
Gabapentin |
0 |
No |
|
Lacosamide |
15 |
No |
|
Lamotrigine |
55 |
No |
|
Levetiracetam |
0 |
No |
|
Oxcarbazepine |
40 |
No |
|
Pregabalin |
0 |
No |
|
Rufinamide |
30 |
No |
|
Stiripentol |
99 |
Yes |
|
Tiagabine |
96 |
Yes |
|
Topiramate |
15 |
No |
|
Vigabatrin |
0 |
No |
|
Zonisamide |
50 |
No |
|
|
||
|
Salih et al. Nutrition Journal 2010 9:71 doi:10.1186/1475-2891-9-71 |
||
