Table 3

Protein binding of antiepileptic drugs

Drug

Protein binding

Candidate for free drug


Old generation AED

Phenobarbital

40%

No

Phenytoin

90%

Yes

Carbamazepine

80%

Yes

Valproic acid

90-95%

Yes

Primidone

15%

No

Ethosuximide

0%

No

New generation AED

Eslicarbazepine acetate

30

No

Felbamate

25

No

Gabapentin

0

No

Lacosamide

15

No

Lamotrigine

55

No

Levetiracetam

0

No

Oxcarbazepine

40

No

Pregabalin

0

No

Rufinamide

30

No

Stiripentol

99

Yes

Tiagabine

96

Yes

Topiramate

15

No

Vigabatrin

0

No

Zonisamide

50

No


Salih et al. Nutrition Journal 2010 9:71   doi:10.1186/1475-2891-9-71

Open Data