The underlying mechanisms for development of hypertension in the metabolic syndrome.
Yanai H, Tomono Y, Ito K, Furutani N, Yoshida H, Tada N.
Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan. yanaih@jikei.ac.jp
High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.
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PMID: 18416854 [PubMed - indexed for MEDLINE]PMCID: PMC2335113