Figure 2.

Leptin levels decline over time in the study population. Changes in estimated marginal means of serum leptin levels at baseline (month 0), month 6, month 12, month 18 and month 24 in the study population groups according to sex-specific tertiles* of baseline serum leptin: 1. Unadjusted model: P = 0.007 for leptin-by-time interaction; 2. Fully adjusted model (for age, gender, DM status, dialysis vintage, previous cardio-vascular morbidity and fat mass): P = 0.047 for leptin-by-time interaction. *Median (interquartile range) leptin (ng/ml) tertiles for men (n = 64) were 1.70 (1.2-2.4), 10.2 (7.6-13.8) and 38.3 (26.2-81.3) and for women (n = 37) were 15.8 (9.3-18.3), 68.0 (41.4-85.9) and 112.6 (109.2-116.0).