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Effect of fruit and vegetable concentrates on endothelial function in metabolic syndrome: A randomized controlled trial

Ather Ali, Yuka Yazaki, Valentine Y Njike, Yingying Ma and David L Katz*

Author Affiliations

Prevention Research Center, Yale University School of Medicine, Griffin Hospital, 130 Division Street, 2nd Floor, Derby, Connecticut, 06418, USA

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Nutrition Journal 2011, 10:72  doi:10.1186/1475-2891-10-72

Published: 29 June 2011


Background and Objective

Dehydrated fruit and vegetable concentrates provide an accessible form of phytonutrient supplementation that may offer cardioprotective effects. This study assessed the effects of two blends of encapsulated juice powder concentrates (with and without added berry powders) on endothelial function in persons with metabolic syndrome, a risk factor for type 2 diabetes and cardiovascular disease.


Randomized, double blind, placebo controlled crossover clinical trial with three treatment arms. 64 adults with metabolic syndrome were enrolled and received 8-week sequences of each blend of the concentrates and placebo. The primary outcome measure was change in endothelial function (assessed as flow-mediated dilatation of the brachial artery) 2 hr after consuming a 75 g glucose load, after 8-weeks of daily consumption (sustained) or 2 hr after consumption of a single dose (acute). Secondary outcome measures included plasma glucose, serum insulin, serum lipids, and body weight.


No significant between-group differences in endothelial function with daily treatment for 8 weeks were seen. No other significant treatment effects were discerned in glucose, insulin, lipids, and weight.


Encapsulated fruit and vegetable juice powder concentrates did not alter insulin or glucose measures in this sample of adults with metabolic syndrome.

Trial Registration NCT01224743

phytonutrients; dietary supplements; cardiovascular; antioxidant; randomized; fruit; vegetable