Table 4

Effects of selenoprotein genotype of biomarkers of Se status1.

gene

allele position-base

function/protein position

n

plasma Se ng/ml

GPX3 nmol/min/mg

serum SEPP1 ng/ml

buccal cell Se ng/mg prot

urine Se ng/mg creatinine


GPX1

679 T/T

Leu198Leu

28

135.7 ± 19.0a

3.67 ± 0.40

3.34 (2.58, 4.33)2

7.72 (5.10, 11.66)2

55.84 (42.80, 72.85)2

679 T/C

Leu198Pro

113

139.5 ± 23.1a,b

3.60 ± 0.53

3.60 (2.86, 4.54)

8.86 (5.89, 13.31)

56.69 (41.85, 76.78)

679 C/C

Pro198Leu

119

145.9 ± 24.3b

3.67 ± 0.58

3.30 (2.43, 4.49)

8.13 (5.44, 12.15)

53.74 (39.92, 72.35)


GPX4

718-C/C

UTR-3

74

142.0 ± 23.2

3.63 ± 0.53

3.40 (2.65, 4.38)

8.25 (5.34, 12.73)

56.86 (42.31, 76.43)

718-C/T

UTR-3

135

141.3 ± 22.8

3.66 ± 0.56

3.43 (2.55, 4.62)

8.53 (5.86, 12.41)

54.78 (41.71, 71.96)

718-T/T

UTR-3

51

143.9 ± 25.9

3.61 ± 0.53

3.49 (2.75, 4.42)

8.24 (5.25, 12.95)

54.14 (37.88, 77.38)


SEPP1

24731-A/A

Thr234Thr

11

129.7 ± 27.9

3.66 ± 0.49

4.07 (3.55, 4.66)

6.92 (4.64, 10.31)

59.01 (46.36, 75.12)

24731-G/A

Thr234Ala

98

140.1 ± 23.0

3.57 ± 0.56

3.41 (2.55, 4.55)

8.41 (5.46, 12.95)

53.14 (40.52, 69.69)

24731-G/G

Ala234Ala

151

144.2 ± 23.3

3.69 ± 0.53

3.41 (2.61, 4.45)

8.49 (5.75, 12.55)

56.38 (41.15, 77.23)

25191-A/A

UTR-3

31

145.0 ± 28.4

3.76 ± 0.63

3.49 (2.91, 4.18)ab

8.88 (5.70, 13.84)

55.17 (39.58, 76.90)

25191-G/A

UTR-3

115

141.8 ± 21.6

3.63 ± 0.58

3.24 (2.44, 4.31)a

8.55 (5.71, 12.81)

54.40 (39.95, 74.08)

25191-G/G

UTR-3

114

141.5 ± 24.0

3.63 ± 0.47

3.62 (2.75, 4.76)b

8.10 (5.42, 12.09)

56.10 (42.58, 73.92)


SEP15

811-C/C

UTR-3

169

143.2 ± 24.4

3.63 ± 0.55

3.45 (2.72, 4.38)

8.77 (5.85, 13.14)a

56.73 (41.87, 76.87)

811-T/C

UTR-3

81

139.0 ± 21.6

3.67 ± 0.53

3.38 (2.40, 4.74)

7.65 (5.06, 11.57)b

52.45 (39.32, 69.97)

811-T/T

UTR-3

10

145.2 ± 23.1

3.56 ± 0.43

3.67 (3.10, 4.35)

8.27 (6.16, 11.10)ab

53.61 (44.36, 64.80)


1 155 women, 106 men

2 geometric mean (-1SD, +1SD)

3 Values within a gene-biomarker group having the same lettered superscript were not significantly different (p > 0.05)

Combs et al. Nutrition Journal 2011 10:75   doi:10.1186/1475-2891-10-75

Open Data