Table 4 |
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|
Effects of selenoprotein genotype of biomarkers of Se status1. |
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|
gene |
allele position-base |
function/protein position |
n |
plasma Se ng/ml |
GPX3 nmol/min/mg |
serum SEPP1 ng/ml |
buccal cell Se ng/mg prot |
urine Se ng/mg creatinine |
|
|
||||||||
|
GPX1 |
679 T/T |
Leu198Leu |
28 |
135.7 ± 19.0a |
3.67 ± 0.40 |
3.34 (2.58, 4.33)2 |
7.72 (5.10, 11.66)2 |
55.84 (42.80, 72.85)2 |
|
679 T/C |
Leu198Pro |
113 |
139.5 ± 23.1a,b |
3.60 ± 0.53 |
3.60 (2.86, 4.54) |
8.86 (5.89, 13.31) |
56.69 (41.85, 76.78) |
|
|
679 C/C |
Pro198Leu |
119 |
145.9 ± 24.3b |
3.67 ± 0.58 |
3.30 (2.43, 4.49) |
8.13 (5.44, 12.15) |
53.74 (39.92, 72.35) |
|
|
|
||||||||
|
GPX4 |
718-C/C |
UTR-3 |
74 |
142.0 ± 23.2 |
3.63 ± 0.53 |
3.40 (2.65, 4.38) |
8.25 (5.34, 12.73) |
56.86 (42.31, 76.43) |
|
718-C/T |
UTR-3 |
135 |
141.3 ± 22.8 |
3.66 ± 0.56 |
3.43 (2.55, 4.62) |
8.53 (5.86, 12.41) |
54.78 (41.71, 71.96) |
|
|
718-T/T |
UTR-3 |
51 |
143.9 ± 25.9 |
3.61 ± 0.53 |
3.49 (2.75, 4.42) |
8.24 (5.25, 12.95) |
54.14 (37.88, 77.38) |
|
|
|
||||||||
|
SEPP1 |
24731-A/A |
Thr234Thr |
11 |
129.7 ± 27.9 |
3.66 ± 0.49 |
4.07 (3.55, 4.66) |
6.92 (4.64, 10.31) |
59.01 (46.36, 75.12) |
|
24731-G/A |
Thr234Ala |
98 |
140.1 ± 23.0 |
3.57 ± 0.56 |
3.41 (2.55, 4.55) |
8.41 (5.46, 12.95) |
53.14 (40.52, 69.69) |
|
|
24731-G/G |
Ala234Ala |
151 |
144.2 ± 23.3 |
3.69 ± 0.53 |
3.41 (2.61, 4.45) |
8.49 (5.75, 12.55) |
56.38 (41.15, 77.23) |
|
|
25191-A/A |
UTR-3 |
31 |
145.0 ± 28.4 |
3.76 ± 0.63 |
3.49 (2.91, 4.18)ab |
8.88 (5.70, 13.84) |
55.17 (39.58, 76.90) |
|
|
25191-G/A |
UTR-3 |
115 |
141.8 ± 21.6 |
3.63 ± 0.58 |
3.24 (2.44, 4.31)a |
8.55 (5.71, 12.81) |
54.40 (39.95, 74.08) |
|
|
25191-G/G |
UTR-3 |
114 |
141.5 ± 24.0 |
3.63 ± 0.47 |
3.62 (2.75, 4.76)b |
8.10 (5.42, 12.09) |
56.10 (42.58, 73.92) |
|
|
|
||||||||
|
SEP15 |
811-C/C |
UTR-3 |
169 |
143.2 ± 24.4 |
3.63 ± 0.55 |
3.45 (2.72, 4.38) |
8.77 (5.85, 13.14)a |
56.73 (41.87, 76.87) |
|
811-T/C |
UTR-3 |
81 |
139.0 ± 21.6 |
3.67 ± 0.53 |
3.38 (2.40, 4.74) |
7.65 (5.06, 11.57)b |
52.45 (39.32, 69.97) |
|
|
811-T/T |
UTR-3 |
10 |
145.2 ± 23.1 |
3.56 ± 0.43 |
3.67 (3.10, 4.35) |
8.27 (6.16, 11.10)ab |
53.61 (44.36, 64.80) |
|
|
|
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|
1 155 women, 106 men 2 geometric mean (-1SD, +1SD) 3 Values within a gene-biomarker group having the same lettered superscript were not significantly different (p > 0.05) |
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|
Combs et al. Nutrition Journal 2011 10:75 doi:10.1186/1475-2891-10-75 |
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