Table 3

A summary of four included probiotic studies
Costalos 2003 [[39] Indrio 2008 [[42] Reuman 1986 [[41] Stratiki 2007 [[40]
Location of study Athens, Greece University of Bari, Policinico, Italy Gainesville, Florida, USA Alexandra Regional Hospital, Greece
Participants - inclusion criteria 28 - 32 weeks gestation 3- 5 days old, appropriate for gestational age, preterm infants with normal agpar scores Premature infants, <2000g at birth, less than 72 hours old (>24 old to <72 hours old) 27 to 37 weeks gestation, in stable state
Number of study participants Study group=51 , Placebo = 36 Study group = 10 , Placebo = 10 Study group = 15, Placebo = 15 Study group = 41, Placebo = 34
Probiotic bacteria used Saccharomyces Bourlardii Lactobacillus Reuteri ATCC 55730 Lactobacillus acidophilus Bifidobacteriumlactis
Dose of probiotic 109cfu at 50mg/kg every 12 hours 1 X 108cfu/day 9 X 106cfu/ml formula 2 X 107cfu/g milk powder
Placebo Maltodextrin Indistinguishable placebo Conventional preterm formula Conventional preterm formula
Dose of placebo 50 mg /kg / 12 hours Not reported
Treatment initiation 1st week of life as soon as enteral feed was tolerated At 3–5 days of life 1st 72 hours of life 1st 2 days of life
Treatment duration 30 days 30 days Not specified 30 days
Reported Outcomes
Growth parameters Weight gain Weight gain Weight gain Weight gain, Linear growth, Head circumference
Timing and duration of measurement of growth parameters Measured daily for 30 days Measured daily for 30 days Measured daily, duration not specified Weight gain: measured daily, Lineargrowth (measured weekly), Head circumference (measured weekly)
Feed tolerance Number of days to full enteral feed, Maximal enteral feed, vomiting Number of days to full enteral feed, Maximal enteral feed, vomiting Maximal enteral feed Number of days to full enteral feed, Maximal enteral feed
Stool characteristics Stooling frequency
Complications NEC, Sepsis Mortality / death NEC, Sepsis
Intestinal permeability Changes in Intestinal permeability Changes in Intestinal permeability
Changes in gastrointestinal microflora cfu of bifidobacteria, lactobacillus, pathogens cfu of bifidobacteria

Mugambi et al.

Mugambi et al. Nutrition Journal 2012 11:58   doi:10.1186/1475-2891-11-58

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