Table 1 |
||||
| Hazard ratios for disease progression in breast cancer patients | ||||
| All (N = 980) | Events (N = 141) | Model 1a | Model 2b | |
| Age (mean(SD)) | 48 (9.8) | 49 (11.7) | 1.02 (1.00-1.04) | 1.01 (0.99-1.03) |
| ≤39 | 191 (19.5) | 30 (21.3) | 1.00 | 1.00 |
| 40-49 | 422 (43.0) | 50 (35.5) | 0.86 (0.54-1.36) | 0.76 (0.48-1.22) |
| 50-59 | 241 (24.6) | 34 (24.1) | 1.02 (0.62-1.70) | 0.83 (0.48-1.42) |
| ≥60 | 126 (12.9) | 27 (19.1) | 1.66 (0.97-2.82) | 1.21 (0.67-2.18) |
| Menopausal status | ||||
| Pre | 610 (63.0) | 74 (53.6) | 1.00 | 1.00 |
| Post | 359 (37.0) | 64 (46.4) | 1.50 (0.93-2.42) | 1.38 (0.85-2.25) |
| BMI, kg/m2 (mean(SD)) | 23 (2.9) | 23 (3.2) | 0.98 (0.92-1.04) | 0.97 (0.91-1.03) |
| <25 | 753 (77.6) | 107 (77.0) | 1.00 | 1.00 |
| ≥25 | 217 (22.4) | 32 (23.0) | 0.85 (0.56-1.28) | 0.79 (0.52-1.20) |
| Education | ||||
| Middle school | 224 (22.9) | 46 (32.6) | 1.00 | 1.00 |
| High school | 402 (41.2) | 56 (39.7) | 0.68 (0.45-1.05) | 0.69 (0.45-1.05) |
| College | 351 (35.9) | 39 (27.7) | 0.58 (0.36-0.94) | 0.58 (0.36-0.93) |
| Alcohol drinking | ||||
| <1/month | 559 (57.5) | 85 (60.7) | 1.00 | 1.00 |
| 1-3/month | 354 (36.4) | 46 (32.9) | 0.83 (0.57-1.21) | 0.83 (0.57-1.22) |
| 1+/week | 59 (6.1) | 9 (6.4) | 1.12 (0.56-2.25) | 1.09 (0.54-2.19) |
| Recruited sites | ||||
| SNU | 511 (52.1) | 73 (51.8) | 1.00 | 1.00 |
| AMC | 469 (47.9) | 68 (48.2) | 0.92 (0.65-1.30) | 0.89 (0.63-1.26) |
| TNM stage | ||||
| I | 400 (40.8) | 25 (17.7) | 1.00 | 1.00 |
| II | 416 (42.5) | 72 (51.1) | 2.78 (1.74-4.44) | 2.71 (1.69-4.35) |
| III | 164 (16.7) | 44 (31.2) | 4.27 (2.57-7.11) | 4.17 (2.50-6.96) |
| Tumor size | ||||
| <2 cm | 526 (54.9) | 42 (29.8) | 1.00 | 1.00 |
| ≥2 cm | 431 (44.9) | 99 (70.2) | 2.57 (1.74-3.79) | 2.51 (1.70-3.72) |
| Tx | 2 (0.2) | |||
| Lymph node status | ||||
| Negative | 577 (58.9) | 60 (42.6) | 1.00 | 1.00 |
| Positive | 390 (39.8) | 78 (55.3) | 1.47 (1.03-2.11) | 1.46 (1.02-2.09) |
| Nx | 13 (1.3) | 3 (2.1) | ||
| Hormone status | ||||
| ER + and/or PR+ | 698 (72.6) | 74 (53.6) | 1.00 | 1.00 |
| ER–/PR– | 264 (27.4) | 64 (46.4) | 2.06 (1.41-3.01) | 2.06 (1.40-3.02) |
| Nuclear grade | ||||
| I-II | 525 (55.2) | 57 (41.0) | 1.00 | 1.00 |
| III | 426 (44.8) | 82 (59.0) | 1.15 (0.78-1.69) | 1.12 (0.75-1.65) |
Abbreviation: AMC, Asan Medical Center; ER, estrogen receptor; PR, progesterone receptor; SNU, Seoul National University.
Data are presented as frequency (percentage), except for age and BMI in continuous variable, which are expressed as mean (SD).
a Adjusted for age, TNM stage and hormone status and nuclear grade.
b Adjusted for age, education, recruited site, TNM stage, hormone status and nuclear grade.
Lee et al. Nutrition Journal 2012 11:59 doi:10.1186/1475-2891-11-59
