Table 2

Association between one-carbon metabolism related nutrients intake and disease progression in breast cancer patients
All (N = 980) Events (N = 141) Model 1a Model 2b
Vitamin B2 intake, mg
 Continuous (mean(SD)) 1.0 (0.4) 1.0 (0.4) 1.21 (0.67-2.18) 1.29 (0.71-2.33)
 1st quartile (0.1-0.6) 192 (19.6) 29 (20.6) 1.00 1.00
 2nd quartile (0.7-0.8) 226 (23.1) 26 (18.4) 0.94 (0.54-1.61) 0.99 (0.58-1.73)
 3rd quartile (0.9-1.1) 295 (30.1) 44 (31.2) 1.20 (0.71-2.02) 1.28 (0.75-2.18)
 4th quartile (1.2-3.4) 267 (27.2) 42 (29.8) 1.40 (0.76-2.61) 1.58 (0.84-2.98)
Ptrend 0.21 0.12
Vitamin B6 intake, mg
 Continuous (mean(SD)) 1.5 (0.5) 1.5 (0.6) 1.41 (0.90-2.20) 1.38 (0.88-2.17)
 1st quartile (0.1-1.0) 174 (17.8) 26 (18.4) 1.00 1.00
 2nd quartile (1.1-1.3) 262 (26.7) 39 (27.7) 1.27 (0.75-2.16) 1.28 (0.75-2.18)
 3rd quartile (1.4-1.7) 238 (24.3) 27 (19.2) 0.97 (0.72-1.80) 0.98 (0.53-1.83)
 4th quartile (1.8-4.8) 306 (31.2) 49 (34.8) 1.61 (0.82-3.16) 1.65 (0.84-3.24)
Ptrend 0.29 0.27
Folate intake, mg
 Continuous (mean(SD)) 213.8 (99.3) 212.9 (98.3) 1.00 (0.99-1.00) 1.00 (0.99-1.00)
 1st quartile (9–147) 240 (24.5) 37 (26.2) 1.00 1.00
 2nd quartile (148–199) 248 (25.3) 32 (22.7) 0.82 (0.51-1.33) 0.82 (0.51-1.34)
 3rd quartile (200–256) 247 (25.2) 33 (23.4) 0.96 (0.58-1.60) 0.97 (0.58-1.63)
 4th quartile (257–970) 245 (25.0) 39 (27.7) 1.18 (0.68-2.03) 1.20 (0.69-2.07)
Ptrend 0.50 0.46
Combined score
 Low (0) 302 (30.8) 44 (31.2) 1.00 1.00
 Medium (1–2) 289 (29.5) 35 (24.8) 0.92 (0.58-1.47) 0.93 (0.58-1.50)
 High (3) 389 (39.7) 62 (44.0) 1.40 (0.84-2.33) 1.46 (0.87-2.43)
Ptrend 0.20 0.15

Data are presented as frequency (percentage), except for continuous variable, which are expressed as mean (SD).

a Adjusted for age, TNM stage, hormone status, nuclear grade and total calorie.

b Adjusted for age, education, recruited site, TNM stage, hormone status, nuclear grade and total calorie.

Lee et al.

Lee et al. Nutrition Journal 2012 11:59   doi:10.1186/1475-2891-11-59

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