Table 3

Association between median of one-carbon metabolism related nutrients and disease progression in breast cancer patients stratified by clinicopathological characteristics
Below median Above median
No. of total No. of events No. of total No. of events HR (95%CI)a
TNM stage
Vitamin B2, mg I-II 350 39 466 58 1.40 (0.85-2.30)
III 68 16 96 28 1.13 (0.52-2.43)
Vitamin B6, mg I-II 362 46 454 51 1.02 (0.61-1.73)
III 74 19 90 25 1.05 (0.49-2.27)
Folate, mg I-II 397 48 419 49 1.10 (0.69-1.75)
III 91 21 73 23 1.52 (0.77-3.01)
Lymph-node status
Vitamin B2, mg Negative 242 25 335 35 1.28 (0.67-2.42)
Positive 172 29 218 49 1.40 (0.81-2.44)
Vitamin B6, mg Negative 251 28 326 32 1.22 (0.63-2.34)
Positive 181 36 209 42 0.88 (0.49-1.56)
Folate, mg Negative 284 30 293 30 1.23 (0.68-2.24)
Positive 199 38 191 40 1.12 (0.67-1.87)
Hormone status
Vitamin B2, mg ER + and/or PR+ 300 34 398 40 0.91 (0.52-1.59)
ER–/PR– 111 21 153 43 2.28 (1.20-4.35)
Vitamin B6, mg ER + and/or PR+ 305 39 393 35 0.57 (0.32-1.03)
ER–/PR– 125 26 139 38 1.86 (0.97-3.56)
Folate, mg ER + and/or PR+ 333 39 365 35 0.82 (0.49-1.40)
ER–/PR– 148 30 116 34 1.84 (1.02-3.32)
Nuclear grade
Vitamin B2, mg I-II 223 23 302 34 1.22 (0.64-2.34)
III 185 32 241 50 1.43 (0.82-2.49)
Vitamin B6, mg I-II 226 29 299 28 0.56 (0.28-1.11)
III 200 36 226 46 1.28 (0.73-2.24)
Folate, mg I-II 250 31 275 26 0.69 (0.38-1.27)
III 224 38 202 44 1.59 (0.95-2.66)

Abbreviation: ER, estrogen receptor; PR, progesterone receptor.

a Adjusted for age, education, recruited site, TNM stage, hormone status, nuclear grade and total calorie.

Lee et al.

Lee et al. Nutrition Journal 2012 11:59   doi:10.1186/1475-2891-11-59

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