Figure 1.

The diagram shows the enzyme points (in cycle) on which the effects of n-3 PUFA might operate in the homocysteine metabolic pathway of relevance. The critical genes in cycle were determined in present study. MTR: 5-methyltetrahydrofolate-homocysteine methyltransferase; MAT: methionine adenosyl transferase; SAHH: S-adenosylhomocysteine hydrolases; CBS: Cystathionine β-synthase; CSE: Cystathionine γ-lyase; MTHFR: Methylenetetrahydrafolate reductase; BHMT: Betaine-homocysteine methyltransferase; DMG: Dimethylglycine; 5, 10-CH₃-THF: 5, 10-Methylene-Tetrahydrofolate; 5-CH₃-THF: 5-Methyl-Tetrahydrofolate; THF: Tetrahydrofolate; SHMT: Serine hydroxymethyl transferase; Pi: Orthophosphate; PPi: Pyrophosphate.