Table 5

Parameters for hepatic function
NGLCD LFD
Baseline 12 months Mean change Baseline 12 months Mean change
AST (IU/l) 48 (22–65.5) 40.5 (24.6-60.7) −6.2 ± 18.2* [−11,1,-1.4] 58 (29.5-85.7) 47.5 (29–62) −8.7 ± 21.6# [−14.8, -2.7]
ALT (IU/l) 57.5 (22–78) 42 (27.3-68) −10.6 ± 19.8* [−15.9, -5.4] 67 (41.2-102) 46 (33–67.7) −11.8 ± 32.2# [−20.8, -2.8]
GGT (IU/l) 46.5 (29–67.5) 39.5 (23.7-55) −9 ± 16 * [−13.2, -4.8] 62 (45–76) 42 (35–61.5) −12.1 ± 12.4# [−15.6, -8.6]
Albumin (g/dl) 4.3 ± 0.3 4.3 ± 0.3 0.06 ± 0.3 ** [−0.01,-0.14] 4.2 ± 0.4 4.2 ± 0.3 0.06 ± 0.3## [−0.02, 0.15]
AST/ALT 0.95 ± 0.37 0.96 ± 0.26 0.01-0.3 *** [−0.07,-0.09] 0.89 ± 0.31 0.92 ± 0.2 0.02 ± 0.32# [−.06, 0.12]
APRI 0.47 (0.3-0.82) 0.45 (0.27-0.69) −0.1 ± 0.27* [−0.17, -0.03] 0.73 (0.31-0.93) 0.53 (0.28-0.71) −0.13 ± 0.32### [−0.2, -0.1]
FI 5.5 ± 1.1 5.3 ± 1.1 −0.2 ± 0.35* [−0.29, -0.1] 5.5 ± 1.3 5.3 ± 1.3 −0.2 ± 0.31# [−0.3, -0.1]

Values are means ± SD; for variables abnormally distributed we used median ± interquartile ranges (25th and 75th percentiles).

All p >0.05 for difference between groups at baseline and 12 months; *, p < 0.05 for mean change baseline, 12 months; #, p < 0.05 for mean change baseline, 12 months; **, p = 0.295; ***, p = 0.925; ##, p = 0.539; ###, p = 0.108.

NGLCD normoglucidic low-calorie diet, LFD low-fat diet, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT gamma-glutamyl transpeptidase, APRI AST to platelet ratio index, FI Forns fibrosis index.

Rusu et al.

Rusu et al. Nutrition Journal 2013 12:119   doi:10.1186/1475-2891-12-119

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