Table 4

Descriptive statistics of dietary nitrate, nitrite, and nitrosamine intake and oral cleft defects in offspring
N (%)
    Outcome N Mean (SD) Quartile 1 Quartile 2 Quartile 3 Quartile 4
Nitrate (mg/day)
Cleft lip only 613 50.31 (52.16) 165 (26.9) 162 (26.4) 139 (22.7) 147 (24.0)
Cleft lip with cleft palate 1133 48.65 (37.08) 293 (25.9) 309 (27.3) 273 (24.1) 258 (22.8)
Cleft palate only 910 49.86 (36.66) 230 (25.3) 233 (25.6) 224 (24.6) 223 (24.5)
Cleft lip with or without cleft palate 1746 49.23 (42.97) 458 (26.2) 471 (27.0) 412 (23.6) 405 (23.2)
Nitrite (mg/day)
Cleft lip only 614 1.75 (0.97) 166 (27.0) 136 (22.1) 158 (25.7) 154 (25.1)
Cleft lip with cleft palate 1133 1.88 (1.06) 263 (23.2) 262 (23.1) 275 (24.3) 333 (29.4)
Cleft palate only 910 1.72 (0.96) 257 (28.2) 211 (23.2) 228 (25.1) 214 (23.5)
Cleft lip with or without cleft palate 1747 1.83 (1.03) 429 (24.6) 398 (22.8) 433 (24.8) 487 (27.9)
Animal Nitrite (mg/day)
Cleft lip only 615 1.11 (0.75) 151 (24.6) 149 (24.2) 144 (23.4) 171 (27.8)
Cleft lip with cleft palate 1140 1.17 (0.78) 262 (23.0) 275 (24.1) 269 (23.6) 334 (29.3)
Cleft palate only 918 1.07 (0.71) 249 (27.1) 219 (23.9) 230 (25.1) 220 (24.0)
Cleft lip with or without cleft palate 1755 1.15 (0.77) 413 (23.5) 424 (24.2) 413 (23.5) 505 (28.8)
Plant Nitrite (mg/day)
Cleft lip only 614 0.64 (0.38) 153 (24.9) 160 (26.1) 162 (26.4) 139 (22.6)
Cleft lip with cleft palate 1140 0.71 (0.49) 280 (24.6) 274 (24.0) 261 (22.9) 325 (28.5)
Cleft palate only 914 0.65 (0.41) 242 (26.5) 221 (24.2) 251 (27.5) 200 (21.9)
Cleft lip with or without cleft palate 1754 0.69 (0.45) 433 (24.7) 434 (24.7) 423 (24.1) 464 (26.5)
Nitrosamine (μg/day)
Cleft lip only 614 0.72 (4.60) 169 (27.5) 126 (20.5) 171 (27.9) 148 (24.1)
Cleft lip with cleft palate 1133 0.53 (0.31) 302 (26.7) 269 (23.7) 283 (25.0) 279 (24.6)
Cleft palate only 908 0.52 (0.30) 264 (29.1) 226 (24.9) 209 (23.0) 209 (23.0)
Cleft lip with or without cleft palate 1747 0.60 (2.74) 471 (27.0) 395 (22.6) 454 (26.0) 427 (24.4)

Huber et al.

Huber et al. Nutrition Journal 2013 12:34   doi:10.1186/1475-2891-12-34

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