## Table 3 |
|||

Primary efficacy variables after randomization and after 8 weeks of intervention |
|||

Intervention |
OPLE-500 |
OPLE-1000 |
FICUS |

Fasting Plasma Glucose (mg/dL) | |||

*Initial | 106±11 | 103±10 | 104±14 |

^{†}Final |
99±10 | 98±8 | 106±16 |

Change | −7.7±7 | −5±7 | −1±8 |

p value for change | p=0.02 | p=0.06 | p=0.61 |

^{₤}Fasting Plasma Insulin (U/ml) |
|||

*Initial | 14.4±11.2 | 8.0±4.3 | 13.1±5.4 |

^{†}Final |
9.1±5.8 | 8.6±6.1 | 11.0±6.0 |

Change | −5.4±7.2 | 0.6±4.2 | −2.1±8.1 |

p value for change | p=0.04 | p=0.96 | p=0.14 |

^{₤}Insulin Sensitivity (%) |
|||

^{‡}Initial |
91 (75) | 137 (122) | 77 (72) |

^{‡}Final |
172 (123) | 136 (119) | 114 (93) |

%Change | 87±113 | 7±41 | 91±25 |

p value for change | p=0.03 | p=0.92 | p=0.57 |

^{₤}Insulin Resistance |
|||

^{‡}Initial |
1.66 (1.34) | 0.93 (0.83) | 1.50 (1.40) |

^{‡}Final |
1.04 (0.82) | 0.98 (0.84) | 1.27 (1.07) |

% Change | −31%±36 | −14%±72 | −8%±42 |

p value for change | p=0.055 | p=0.92 | p=0.65 |

*Initial values from the baseline OGTT pre-dose sample at the time of randomization to study. Values are given as the mean ± SD.

^{†}Final values from the baseline OGTT pre-dose sample after 8 weeks of intervention.
Values are given as the mean ± SD.

^{‡}Values are given as the mean (geometric mean).

^{₤}For each continuous variable at each time point, the mean differences in the variable
or in the change in that variable from baseline between the different products was
tested for nominal significance by the one-way analysis of variance (ANOVA) or by
the non-parametric Kruskal-Wallis test if non-normally distributed. This applied to
all of the insulin calculations.

Kalman * et al.*

Kalman * et al.* *Nutrition Journal* 2013 **12**:36 doi:10.1186/1475-2891-12-36