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Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan

Heike Stier1*, Veronika Ebbeskotte2 and Joerg Gruenwald1

Author Affiliations

1 analyze & realize GmbH, Waldseeweg 6, 13467 Berlin, Germany

2 Leiber GmbH, Hafenstraße 24, 49565 Bramsche, Germany

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Nutrition Journal 2014, 13:38  doi:10.1186/1475-2891-13-38

Published: 28 April 2014


Beta-glucans are a heterogeneous group of natural polysaccharides mostly investigated for their immunological effects. Due to the low systemic availability of oral preparations, it has been thought that only parenterally applied beta-glucans can modulate the immune system. However, several in vivo and in vitro investigations have revealed that orally applied beta-glucans also exert such effects. Various receptor interactions, explaining possible mode of actions, have been detected. The effects mainly depend on the source and structure of the beta-glucans. In the meantime, several human clinical trials with dietary insoluble yeast beta-glucans have been performed. The results confirm the previous findings of in vivo studies. The results of all studies taken together clearly indicate that oral intake of insoluble yeast beta-glucans is safe and has an immune strengthening effect.

Insoluble yeast β-glucans; Immune system; Clinical trial