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Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study

Na Hee Ryu1, Yeni Lim1, Ji Eeun Park1, Joohee Kim2, Ji Yeon Kim3, Sung Won Kwon4* and Oran Kwon124*

Author Affiliations

1 Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Republic of Korea

2 BioFood Network, Ewha Womans University, Seoul 120-750, Republic of Korea

3 Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 139-743, Republic of Korea

4 CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do 463-712, Republic of Korea

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Nutrition Journal 2014, 13:57  doi:10.1186/1475-2891-13-57

Published: 11 June 2014



High level of serum cholesterol is considered to be a major risk factor for cardiovascular disease (CVD). A double-blinded, randomized, placebo-controlled trial was performed to test the hypothesis that a daily intake of Chlorella may improve serum lipid profile through enhancement of serum carotenoid concentration in mildly hypercholesterolemic subjects.


Eligible subjects (n = 63) were randomized to either Chlorella (5 g/day) or placebo for a double-blinded trial with a 2-week lead-in period and a 4-week intervention period. Serum triglycerides, total cholesterol, lipoproteins, apolipoproteins and carotenoids were assessed at the beginning and the end of the trial.


Compared with the control group, the Chlorella group exhibited remarkable changes in total cholesterol (Chlorella −1.6%; placebo 0.03%; P = 0.036), triglycerides (Chlorella −10.3%; placebo 11.9%; P = 0.002), lutein/zeaxanthin (Chlorella 89.6%; placebo −1.7%; P < 0.0001), and α-carotene (Chlorella 163.6%; placebo 15%; P < 0.0001). Improvement of serum lipids was supported by significant reductions of very low-density lipoprotein cholesterol (Chlorella −11%; placebo 11.8%; P = 0.006), apolipoprotein B (Chlorella −1.5%; placebo 1.7%; P = 0.044), non high-density lipoprotein (Chlorella −2.6%; placebo −0.5%; P = 0.032), and high-density lipoprotein/triglycerides (Chlorella 4.0%; placebo −9.5%; P = 0.023), suggesting an inhibitory effect of Chlorella on the intestinal absorption of dietary and endogenous lipids. Further, the changes of serum lipids appeared to be associated with the changes of serum carotenoids.


Daily consumption of Chlorella supplements provided the potential of health benefits reducing serum lipid risk factors, mainly triglycerides and total cholesterol, in mildly hypercholesterolemic subjects. The effect was related to carotenoid consumption.

Trial registration

WHO International Clinical Trials Registry Platform KCT0000259.

Chlorella; Serum lipid; Carotenoids; Human