Table 2

Effects of probiotic administration on diabetes mellitus – clinical studies
References Probiotic Study design/subjects Sample Size Quantity Study period Results
[8] Lactobacillus acidophilus and Bifidobacterium bifidum Double-blinded, placebo-controlled, randomized study, T2D females aged 50–65 years Placebo group: n = 10; Probiotic group: n = 10 2 daily doses of 100 mL symbiotic shake containing 4 × 108 CFU/100 mL Lactobacillus acidophillus, 4 × 108 CFU/100 mL Bifidobacterium bifidum 45 days ↓ Glycemia
[9] Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 Double-blinded, randomized controlled clinical trial, T2D patients aged 30–60 years Placebo group: n = 32; Probiotic group: n = 32 300 g/day of probiotic and conventional yogurt day 1: 7,23 × 106 of L. acidophilus La5 and 6.04 × 106 cfu/g of B. lactis Bb12 6 weeks ↓ Fasting blood glucose and HbA1c
↑ Erythrocyte SOD and GPx
↑ Total antioxidant capacity
[10] L. acidophilus NCFM Double-blinded, placebo-controlled, randomized study, T2D males Placebo group: n = 24; Probiotic group: n = 24 - 4 weeks Preserved insulin sensitivity
No effect on systemic inflammatory response
[117] Lactobacillus rhamnosus GG (ATCC 53 103) and Bifidobacterium lactis Bb12 Prospective, randomized study, mother–baby pairs Dietetic Intervention + probiotics: n = 85; Dietetic Intervention + placebo: n = 86; Control + placebo: n = 85 Lactobacillus rhamnosus GG: 1010 CFU/day; Bifidobacterium lactis Bb12: 1010 CFU/day 33 months ↓ Risk of GDM
[118] Lactobacillus rhamnosus GG, ATCC 53 103 and Bifidobacterium lactis Bb12 Randomized, prospective, parallel-group, combined dietary counselling, pregnant women Diet + probiotics: n = 85; Diet + placebo: n = 86; Control + placebo: n = 85 Lactobacillus rhamnosus: 1010 CFU/day; Bifidobacterium lactis Bb12: 1010 CFU/day 18 months ↓ Blood glucose
↓ Insulin
↓ Insulin sensitivity
[119] L. plantarum WCFS1 Double-blinded, randomized crossover study, healthy subjects n = 14 1012 CFU 6 hours ↓ Degradation of transepithelial electrical resistance
↑ ZO-1 in tight junctions

GDM: gestational diabetes mellitus; GPx: Glutathione peroxidase; HbA1c: Glycated hemoglobin; SOD: Superoxide dismutase; T2D: type II diabetes mellitus; ZO-1: zonula occludens-1.

Gomes et al.

Gomes et al. Nutrition Journal 2014 13:60   doi:10.1186/1475-2891-13-60

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