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A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial

Hideki Nakayama1*, Nobuaki Tsuge2, Hiroshi Sawada2, Noriya Masamura2, Shohei Yamada1, Shigeki Satomi1 and Yukihito Higashi3

Author Affiliations

1 Research & Development Institute, House Foods Corporation, Yotsukaido 284-0033, Japan

2 Central Research & Development Institute, House Foods Group Inc., Yotsukaido 284-0033, Japan

3 Department of Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan

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Nutrition Journal 2014, 13:67  doi:10.1186/1475-2891-13-67

Published: 28 June 2014



Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol. Oxidative stress is thought to impair endothelial function associated with atherosclerosis, a leading cause of cardiovascular events. The aim of this study was to determine whether a single consumption of curry meal would improve endothelial function in healthy men.


Fourteen healthy male subjects (BMI 23.7 ± 2.7 kg/m2; age 45 ± 9 years) were given a single serving of curry meal or spice-free control meal (180 g of curry or control and 200 g of cooked rice; approximately 500 kcal in total) in a randomized, controlled crossover design. Before and 1 hr after the consumption, fasting and postprandial flow-mediated vasodilation (FMD) responses and other parameters were measured.


The consumption of the control meal decreased FMD from 5.8 ± 2.4% to 5.1 ± 2.3% (P = 0.039). On the other hand, the consumption of the curry meal increased FMD from 5.2 ± 2.5% to 6.6 ± 2.0% (P = 0.001), and the postprandial FMD after the curry meal was higher than that after the control meal (P = 0.002). Presence of spices in the curry did not alter significantly the systemic and forearm hemodynamics, or any biochemical parameters including oxidative stress markers measured.


These findings suggest that the consumption of curry ameliorates postprandial endothelial function in healthy male subjects and may be beneficial for improving cardiovascular health.

Trial registration

UMIN Clinical Trials Registry 000012012.

Curry; Spice; Antioxidant; Endothelial function; Postprandial hyperglycemia; Flow-mediated vasodilation; Prevention; Cardiovascular events