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Effects of control and soy foods on serum and urinary markers of bone metabolism |
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| Measures |
Control (n = 27) |
Soy (n = 35) |
Control vs Soy |
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| Baseline |
6 months |
Final |
Baseline |
6 months |
Final |
P values |
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| Trtmt |
Time |
Trtmt × Time |
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|
|
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| Serum |
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|
|
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| IGF-I (nmol/L) |
17.9 ± 1.4b |
20.5 ± 1.4a |
20.2 ± 1.4a |
13.3 ± 1.2c |
16.8 ± 1.2ab |
16.8 ± 1.2ab |
0.023 |
< 0.001 |
0.693 |
| IGFBP3 (ng/mL) |
3833 ± 133 |
3934 ± 133 |
3904 ± 135 |
3442 ± 120b |
3751 ± 120a |
3622 ± 121a |
0.087 |
0.005 |
0.252 |
| Osteocalcin (ng/mL) |
8.3 ± 2.1b |
13.9 ± 2.1a |
16.2 ± 2.2a |
8.9 ± 1.9b |
17.4 ± 2.0a |
18.1 ± 2.0a |
0.365 |
< 0.001 |
0.671 |
| BSAP (U/L) |
19.8 ± 1.2c |
23.3 ± 1.2b |
25.3 ± 1.2a |
19.8 ± 1.1c |
22.6 ± 1.1b |
24.9 ± 1.1a |
0.796 |
< 0.001 |
0.818 |
| ALP (U/L) |
57.4 ± 3.0c |
65.9 ± 3.0b |
74.0 ± 3.1a |
56.6 ± 2.7c |
69.1 ± 2.7b |
74.3 ± 2.8a |
0.798 |
< 0.001 |
0.499 |
| Urine |
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| Dpd (nmol/mmol creatinine) |
5.3 ± 0.4 |
5.3 ± 0.4 |
4.9 ± 0.4 |
5.2 ± 0.3 |
5.4 ± 0.3 |
5.1 ± 0.3 |
0.888 |
0.234 |
0.744 |
|
Values are least squares mean ± SE. IGF-I = insulin-like growth factor-I; IGFBP-3 = insulin-like growth factor binding protein-3; BSAP = bone-specific alkaline phosphatase; ALP = alkaline phosphatase; Dpd = deoxypyridinoline. Within each row, values that do not share the same superscript letters are significantly (P < 0.05) different from each other. | |||||||||
Arjmandi et al. Nutrition Journal 2005 4:8 doi:10.1186/1475-2891-4-8 |
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