Figure 1.

Trial profile * No contact after intake. ** In period 1 three SF patients dropped out; 2 patients stopped because of severe constipation; one patient switched to hypoallergenic feeding, because of suspected cow's milk protein allergy. *** Parents of 1 patient decided that they did not want to cross-over because she was free of symptoms and they started openly with NF instead. **** Three patients dropped out after switching to NF; 2 patients stopped after less than 1 week because of recurrence of constipation symptoms. 1 patient was lost to follow-up. ***** Seven patients dropped out after switching to SF; 6 patients stopped after one week because of recurrence of constipation symptoms. 1 patient was lost to follow-up.