Table 2 |
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Serum albumin and survival - lung cancer |
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|
First author, year of publication, place |
Year of data collection |
Study design, Sample size |
Cancer type |
Groups being compared |
RR (95%Cl), p-value |
Variables adjusted for |
|
|
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|
Win T, 2008, UK [70] |
2 years up to December 2006 |
Prospective consecutive case series, 110 |
Non Small Cell Lung |
Continuous variable |
Univariate: 0.93 (0.88-0.98), 0.006 |
Female gender, age, pneumectomy, chronic obstructive pulmonary disease, Smoking, Diabetes, Coronary disease, BMI, global quality of life |
|
|
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|
Forrest LM, 2005, UK [71] |
January 2002 to December 2003 |
Prospective, 101 |
Non Small Cell Lung |
>=3.5 g/dL <3.5 g/dL |
Median Survival (months) (95% CI) For >/=3.5 g/dL = 8.7 (6.9-10.5) For <3.5 g/dL = 1.2 (0.0-2.8), p = <0.01 |
Age, sex, stage, hemoglobin, WBC, CRP, PS, GPS, treatment |
|
|
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|
Maeda T, 2000, Japan [9] |
1978-1992 |
Retrospective, 261 |
Non Small Cell Lung |
<3.5 g/dL >=3.5 g/dL |
Median survival in months <3.5 g/dL = 5.0 >=3.5 g/dL = 9.6; p = <0.001 Multivariate: 1.69 (1.19-2.41), 0.0037 |
Age, gender, histology, PS, LFTs, Stage IV, bilirubin, CEA, liver metastases |
|
|
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|
Tas F, 1999, Turkey [10] |
1991 to 1997 |
Retrospective, 207 |
Small Cell Lung |
Normal: >=3.5 g/dL Low: <3.5 g/dL |
Univariate: p = <0.001 Multivariate: p = 0.03 |
Age, gender, performance status, weight loss, clinical stage, hemoglobin, LDH, response to chemotherapy |
|
|
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|
Ray P, 1998, France [4] |
NA |
Retrospective, 99 patients with SCLC and 202 patients with NSCLC |
Small cell lung and Non-Small cell lung |
NA |
Serum albumin levels were not found to be associated with survival |
Tumor, node, metastasis status, PS, body weight loss, WBC, serum sodium, LDH, ALP, serum NSE, serum TPS, and CYFRA 21-1 |
|
|
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|
Lai SL, 1998, Taiwan [72] |
NA |
Prospective, 150 |
Non Small Cell Lung |
NA |
Patients who died within six months after diagnosis had significantly lower values of all nutritional parameters than those who survived more than 6 months |
Weight/height ratio, percent of standard triceps skin-fold thickness, percent of standard arm muscle circumference, transferrin, creatinine height index and total lymphocyte count |
|
|
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|
Maestu I, 1997, Spain [73] |
November 1981 to January 1993 |
Retrospective, 341 |
Small cell lung |
<3.4 g/dL >=3.4 g/dL |
Univariate: 0.0057 Multivariate : coefficient = -0.3457, p = 0.001 |
LDH, disease extent, CK, neutrophils, PS, glycemia, ESR, sodium, potassium, ALP, urea, uric acid, age |
|
|
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|
Muers MF, 1996, UK [74] |
NA |
Retrospective consecutive case series, 207 |
Non Small Cell Lung |
NA |
Prognostic Index = -0.42 × distant metastases + 1.1 × hoarseness + 0.47 × malaise - 0.34 × immediate treatment intent + 0.72 × lymphocyte count + 0.94 × serum albumin + 0.62 × sodium - 0.98 × ALP |
Sex, the activity score, the presence of malaise, hoarseness and distant metastases at presentation, and lymphocyte count, sodium and ALP levels |
|
|
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|
Hespanhol V, 1995, Portugal [75] |
1984 to 1990 |
Prospective, 411 |
Non Small Cell Lung |
<3.5 g/dL >=3.5 g/dL |
Univariate: 1.92, (1.55-2.36), 0.000 Multivariate: 0.588 (0.46-0.74), 0.000 |
PS, Weight loss, Hoarseness, stage, lymphocyte, LDH, sex |
|
|
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|
Espinosa E, 1995, Spain [76] |
1980-1992 |
Retrospective onsecutive case series, 292 |
Non Small Cell Lung |
>=4 g/dL <4 g/dL |
Univariate: Median survival in months For >=4 g/dL = 9 For <4 g/dL = 7, p = 0.004; Multivariate: Coefficient = -2.52, p = 0.0001 |
Number of metastases, LDH, PS, sedimentation rate |
|
|
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Gupta and Lis Nutrition Journal 2010 9:69 doi:10.1186/1475-2891-9-69 |
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